supplements_worradmu_free_digital — Supplement image courtesy of worradmu/FreeDigitalPhotos.net

SAM-e made Consumer Reports* “11 Supplements to Consider” in 2010. SAM-e (S-adenosylmethionine) is a synthetic form of a chemical produced naturally in the body. It is essential to a many chemical processes, including maintaining cells, manufacturing substances used by the nerves, and influencing emotions and moods.

Claims and Purported Use

SAM-e is a “natural” treatment for depression, arthritis, and liver disease. SAM-e is said to be as effective as aspirin for pain relief, without the side effects. Consumer Reports* says that it is likely effective in reducing symptoms of major depression, reducing pain, and improving functioning in people with osteoarthritis. Interestingly, Europe markets sell SAM-e as a prescription drug for depression, arthritis, and liver disease, but in the U.S. and Canada, SAM-e is unregulated.

TESTED & TRUE – MOOD BOOSTER SAM-e

Doctor’s Best – SAM-e

GNC Sam-e 400

Life Extension SAM-e

Nature Made SAM-e

Selected Potential Side Effects

SAM-e may lead to GI symptoms, dry mouth, headache, mild insomnia, anorexia, sweating, dizziness, and nervousness, especially at higher doses. It can cause some people with depression to feel anxious.

Selected Drug Interactions

SAM-e, when taken with the cough suppressant (dextromethorphan), certain antidepressants, or narcotic pain relievers, might lead to a toxic reaction. When taken with the Parkinson’s drug levodopa, SAM-e might worsen symptoms.